Stage 3 is when your new weight is re-set. When you complete Stage 3 as per protocol, your weight will remain stable to within 2 kilos, long-term. In order to gain 1 kg you would need to over-eat by 500 calories a day for approximately 20 days. It is ESSENTIAL that you strictly follow your Stage 3 Plan and ONLY choose foods from the allowed list. Foods that are on the “Forbidden” list will interfere with re- setting your weight, which means you will regain the weight easily.

The hypothalamus is the weight control centre in the brain and works to maintain a stable weight. It receives input from the body and integrates and interprets these signals in order to produce a response The output from the hypothalamus is carried out by hormones and automatic neural pathways that regulate appetite, energy output and metabolism. The hypothalamus also determines how easily you lose and gain weight, when and what you crave, as well as how your body processes macronutrients (carbohydrates, fats and proteins).

If you lose weight, the hypothalamus will receive input from shrinking fat cells and changes from other organs in the body. It will then respond by releasing hormones and neuropeptides that increase appetite and reduce metabolism, resulting in weight gain. This is the reason why so many diets fail.

Research shows that it is possible to modify the output from the hypothalamus and therefore influence long-term weight control.

Neuroplasticity is the process by which the brain develops new pathways in order to change your automatic responses. This is important when it comes to hypothalamic responses and is also the most important factor for developing and establishing behavioural patterns that are conducive with long- term maintenance.

The efficacy of neuroplasticity is dependant on the environment in the brain – and this is determined by input from the body, which in turn depends on what you eat or ingest, your lifestyle and your environment. There many factors have the ability to interfere with neuroplasticity.

The hCG diet plan removes foods that interfere with the process and includes nutrients that assist it. In addition, it is believed that the hCG hormone can help reduce the time it takes for these new neural pathways to form.


hCG is a hormone that, once injected, acts directly on the hypothalmus. hCG is believed to assist with resetting a new stable weight by changing the hormonal input into the hypothalamus and therefore influencing the hormonal and neural output from the hypothalamus. hCG has also been associated with an increase in brain-derived neurotrophic factor (BDNF), a brain protein that is essential for the development of new neurons. The effect of hCG on BDNF is thought to change neural pathways within 3 to 6 weeks and help rapidly re-set a new stable weight. In addition, the hCG hormone is believed to reduce appetite, influence eating patterns and regulate how the body responds to macronutrients. It is possible that these combined effects of hCG can continue well beyond the final injection, which may explain why it is easier to maintain a lower weight on completion of the program.


If you were to follow a normal diet and exercise plan, and lose weight in the traditional way, the neurological process takes much longer. Weight loss normally results in hormonal and neural changes that lead to weight regain. If you are able to overcome these homeostatic responses and successfully lose weight without the help of the hCG, you then face the issue of re-setting this new weight.

When you start to develop a new behavior, such as a new eating pattern, new neural pathways begin to form at around three weeks however it may take up to twelve months before these pathways are used as the preferential automatic neural and hormonal output. Therefore, once you have reached your goal weight and have established a new eating pattern, you must maintain that weight and eating pattern for twelve months for these new neural pathways to become permanent and respond in an automatic pattern. Certain foods, such as those in the Forbidden Food List, may interfere with the release of BDNF and therefore delay or prevent the development of new pathways. This means, that you would need to avoid these foods for at least twelve months in order for your body to establish a neural and hormonal output that is conducive to weight maintenance. This is why only five percent of dieters are successful long-term.

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